RNA Details
Disease Name
silicosis
Tissue
lung
RNA Symbol
Col1a1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Immunohistochemistry; qRT-PCR; Western Blot etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA-205-5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2-mediated Beclin1 ubiquitination
Year
2021
Function
"The expression patterns of the collagen genes collagen type I alpha 1 (Col1a1) and Col3a1 in the alveolar tissues were determined by RT-qRT-PCR, and the Col1a1 and Col3a1 mRNA levels were significantly increased in the alveolar tissues of CS-treated mice."